ncRNA name | hsa-let-7 |
ncRNA Category | miRNA |
Disease name | diabetic retinopathy (DR) |
Species | Homo sapiens |
Tissues/Cell_line | human umbilical vein endothelial cells (HUVECs); human choroidal endothelial cells (HCECs); human retinal endothelial cells (HRECs); RPE cell line ARPE-19 |
Methods | transfection, BrdU incorporation assay, scratch wound assay, qRT-PCR, Western blot |
Expression pattern | associated |
Functional description | Our data establish a causative role of let-7 in non-proliferative diabetic retinopathy and a repressive function of let-7 in pathological angiogenesis. |
PubMed ID | 28584193 |
Year | 2017 |
Title | Let-7 contributes to diabetic retinopathy but represses pathological ocular angiogenesis. |
Drug-related ncRNA | NO |
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