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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name hsa-let-7
ncRNA Category miRNA
Disease name diabetic retinopathy (DR)
Species Homo sapiens
Tissues/Cell_line human umbilical vein endothelial cells (HUVECs); human choroidal endothelial cells (HCECs); human retinal endothelial cells (HRECs); RPE cell line ARPE-19
Methods transfection, BrdU incorporation assay, scratch wound assay, qRT-PCR, Western blot
Expression pattern associated
Functional description Our data establish a causative role of let-7 in non-proliferative diabetic retinopathy and a repressive function of let-7 in pathological angiogenesis.
PubMed ID 28584193
Year 2017
Title Let-7 contributes to diabetic retinopathy but represses pathological ocular angiogenesis.
Drug-related ncRNA NO

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